{"id":10515,"date":"2026-04-23T15:11:40","date_gmt":"2026-04-23T06:11:40","guid":{"rendered":"https:\/\/www.elsi.jp\/?post_type=news_events&#038;p=10515"},"modified":"2026-04-23T15:13:01","modified_gmt":"2026-04-23T06:13:01","slug":"rapid_discovery_high_affinity_antibodies","status":"publish","type":"news_events","link":"https:\/\/www.elsi.jp\/en\/news_events\/highlights\/2026\/rapid_discovery_high_affinity_antibodies\/","title":{"rendered":"Researchers successfully engineered receptor membrane proteins without using living cells"},"content":{"rendered":"<p>(Thia article is available only in Japanese)<br \/>\n&nbsp;<br \/>\n\uff08\u4ee5\u4e0b\u306f\u6771\u4eac\u79d1\u5b66\u5927\u5b66\u306e\u3001\u540d\u53e4\u5c4b\u5927\u5b66\u3001\u5343\u8449\u5927\u5b66\u3001\u5bae\u5d0e\u5927\u5b66\u3068\u306e\u5171\u540c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u3067\u3059\uff09<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u963b\u5bb3\u5264\u611f\u53d7\u6027\u309210\u500d\u5411\u4e0a\u3055\u305b\u305fG\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u5f79\u578b\u53d7\u5bb9\u4f53\u300c\u30a2\u30c7\u30ce\u30b7\u30f32A\u53d7\u5bb9\u4f53\u300d\u306e\u65b0\u898f\u5909\u7570\u4f53\u3092\u540c\u5b9a\u3057\u3001\u7d30\u80de\u7a2e\u7279\u7570\u7684\u306a\u30b7\u30b0\u30ca\u30eb\u5236\u5fa1\u3092\u5b9f\u73fe<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-10455\" src=\"https:\/\/www.elsi.jp\/wp-content\/uploads\/2026\/04\/Matsuura_1.png\" alt=\"\" width=\"600\" height=\"532\" srcset=\"https:\/\/www.elsi.jp\/wp-content\/uploads\/2026\/04\/Matsuura_1.png 600w, https:\/\/www.elsi.jp\/wp-content\/uploads\/2026\/04\/Matsuura_1-300x266.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<div style=\"width: 70%; margin: 0px auto;\">\n<p>\u56f3 1\uff1a\u2f08\u2f2f\u9032\u5316\u306b\u3088\u308a\u5f97\u3089\u308c\u305f A2AR \u5909\u7570\u4f53\u3002A\uff09 NGS \u89e3\u6790\u306e\u7d50\u679c\u3001400 \u7a2e\u985e\u306e\u5909\u7570\u4f53\u306e\u3046\u3061\u2f9a\u3067\u56f2\u3063\u305f\uff12\u3064\u304c\u9855\u8457\u306b\u6fc3\u7e2e\u3055\u308c\u3066\u3044\u305f\u3002B\uff09\u53d6\u5f97\u3057\u305f\uff12\u3064\u306e\u5909\u7570\u4f53\u306f\u3001\u30a2\u30c7\u30ce\u30b7\u30f3\u3067\u306f\u91ce\u2f63\u578b\u3068\u540c\u69d8\u306b\u6d3b\u6027\u5316\u3055\u308c\u305f\u304c\u3001\u963b\u5bb3\u5264\u3092\u52a0\u3048\u305f\u5834\u5408\u306f\u3001\u91ce\u2f63\u578b\u3088\u308a\u3082 10 \u500d\u4f4e\u3044\u963b\u5bb3\u5264\u6fc3\u5ea6\u3067\u52b9\u679c\u304c\u2f92\u3089\u308c\u305f\u3002C\uff09\u5206\u2f26\u52d5\u2f12\u5b66\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u7d50\u679c\u3002\u91ce\u2f63\u578b\u3068\u5909\u7570\u4f53\u306f\u963b\u5bb3\u5264\u3068\u7570\u306a\u308b\u7d50\u5408\u69d8\u5f0f\u3092\u6301\u3064\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<p class=\"c-paragraph\">\u6771\u4eac\u79d1\u5b66\u5927\u5b66\uff08<span lang=\"EN-US\">Science Tokyo<\/span>\uff09\u751f\u547d\u7406\u5de5\u5b66\u9662 \u751f\u547d\u7406\u5de5\u5b66\u7cfb\u306e\u6df1\u6fa4\u5143\u559c\u4fee\u58eb\u8ab2\u7a0b\u5b66\u751f\uff08\u7814\u7a76\u5f53\u6642\uff09\u3001\u5317\u5c3e\u5f70\u6717\u6559\u6388\u3001\u540c\u5927\u5b66 \u5730\u7403\u751f\u547d\u7814\u7a76\u6240\u306e\u677e\u6d66\u53cb\u4eae\u6559\u6388\u3001\u798f\u6c38\u572d\u4f51\u7279\u4efb\u52a9\u6559\uff08\u73fe\uff1a\u5bae\u5d0e\u5927\u5b66 \u7814\u7a76\u30fb\u7523\u5b66\u5730\u57df\u9023\u643a\u63a8\u9032\u6a5f\u69cb \u30c6\u30cb\u30e5\u30a2\u30c8\u30e9\u30c3\u30af\u63a8\u9032\u5ba4 \u51c6\u6559\u6388\uff09\u3001\u540d\u53e4\u5c4b\u5927\u5b66 \u5927\u5b66\u9662\u5de5\u5b66\u7814\u7a76\u79d1 \u677e\u5ca1\u4f51\u771f\u535a\u58eb\u5f8c\u671f\u8ab2\u7a0b\u5b66\u751f\u3001\u6e05\u4e2d\u8302\u6a39\u6559\u6388\u3001\u5343\u8449\u5927\u5b66 \u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u9662 \u6751\u7530\u6b66\u58eb\u6559\u6388\u3089\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u7d30\u80de\u3092\u7528\u3044\u305a\u306b\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5b9f\u9a13\u5ba4\u5185\u3067\u4eba\u5de5\u9032\u5316\u3055\u305b\u308b\u6280\u8853\u3092\u958b\u767a\u3057\u3001\u30ea\u30ac\u30f3\u30c9\u7d50\u5408\u80fd\u304c<span lang=\"EN-US\">10<\/span>\u500d\u7a0b\u5ea6\u5411\u4e0a\u3057\u305f\u30d2\u30c8\u7531\u6765\u30a2\u30c7\u30ce\u30b7\u30f3\u300c<span lang=\"EN-US\">A<sub>2A<\/sub><\/span>\u53d7\u5bb9\u4f53\uff08<span lang=\"EN-US\">A<sub>2A<\/sub>R<\/span>\uff09\u300d\u306e\u5909\u7570\u4f53\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u5909\u7570\u4f53\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u7d30\u80de\u7a2e\u7279\u7570\u7684\u306a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u306e\u5236\u5fa1\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p class=\"c-paragraph\">\u7d30\u80de\u5916\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u7d30\u80de\u5185\u306b\u4f1d\u3048\u308b\u5f79\u5272\u3092\u62c5\u3046\u300c<span lang=\"EN-US\">G<\/span>\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u5f79\u578b\u53d7\u5bb9\u4f53\uff08<span lang=\"EN-US\">GPCR: G Protein-Coupled Receptor<\/span>\uff09\u300d\u306e\u6a5f\u80fd\u3092\u6539\u5909\u3057\u305f\u5909\u7570\u4f53\u3092\u3001\u5408\u7406\u7684\u306b\u8a2d\u8a08\u3059\u308b\u3053\u3068\u306f\u3001\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u67d4\u8edf\u6027\u30fb\u4e0d\u6eb6\u5316\u3057\u3084\u3059\u3044\u7279\u6027\u304b\u3089\u96e3\u3057\u304f\u3001\u591a\u304f\u306e\u8a66\u884c\u932f\u8aa4\u3092\u8981\u3057\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u7121\u7d30\u80de\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u7cfb\u3068\u30ca\u30ce\u30c7\u30a3\u30b9\u30af\u6280\u8853\u3092\u7d44\u307f\u5408\u308f\u305b\u3001<span lang=\"EN-US\">GPCR<\/span>\u306e<span lang=\"EN-US\">1<\/span>\u3064\u3067\u3042\u308b<span lang=\"EN-US\">A<sub>2A<\/sub>R<\/span>\u304c\u6a5f\u80fd\u767a\u73fe\u3059\u308b\u3088\u3046\u6761\u4ef6\u3092\u6700\u9069\u5316\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u5b9f\u9a13\u5ba4\u9032\u5316\u3068\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b5\u30fc\u89e3\u6790\u3092\u7528\u3044\u3066\u3001\u5909\u7570\u4f53\u96c6\u56e3\u304b\u3089\u7279\u5b9a\u306e\u963b\u5bb3\u5264\u306b\u5bfe\u3059\u308b\u7d50\u5408\u80fd\u304c\u5411\u4e0a\u3057\u305f\u5909\u7570\u4f53\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002\u5909\u7570\u4f53\u306f\u3001\u54fa\u4e73\u52d5\u7269\u7d30\u80de\u306b\u304a\u3044\u3066\u30b7\u30b0\u30ca\u30eb\u963b\u5bb3\u6d3b\u6027\u304c<span lang=\"EN-US\">10<\/span>\u500d\u7a0b\u5ea6\u5411\u4e0a\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u5206\u5b50\u6a5f\u69cb\u3092\u539f\u5b50\u30ec\u30d9\u30eb\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3067\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u7372\u5f97\u3055\u308c\u305f\u5909\u7570\u4f53\u306e\u7279\u6027\u3092\u5229\u7528\u3057\u3001\u7d30\u80de\u7a2e\u7279\u7570\u7684\u306b<span lang=\"EN-US\">GPCR<\/span>\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6291\u5236\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u3082\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p class=\"c-paragraph\">\u672c\u7814\u7a76\u3067\u958b\u767a\u3057\u305f\u624b\u6cd5\u306f\u3001\u7d04<span lang=\"EN-US\">10<sup>12<\/sup><\/span>\u7a2e\u985e\u898f\u6a21\u306e<span lang=\"EN-US\">GPCR<\/span>\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u304b\u3089\u76ee\u7684\u306e\u6a5f\u80fd\u3092\u6301\u3064\u5909\u7570\u4f53\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u53ef\u80fd\u3068\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u5275\u85ac\u3084\u30b1\u30e2\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u5206\u91ce\u306b\u304a\u3051\u308b\u65b0\u898f<span lang=\"EN-US\">GPCR<\/span>\u5909\u7570\u4f53\u63a2\u7d22\u306e\u57fa\u76e4\u6280\u8853\u3068\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p class=\"c-paragraph\">\u672c\u6210\u679c\u306f\u3001<span lang=\"EN-US\">3<\/span>\u6708<span lang=\"EN-US\">6<\/span>\u65e5\u4ed8\uff08\u73fe\u5730\u6642\u9593\uff09\u306e\u300c<i><span lang=\"EN-US\">Journal of the American Chemical Society<\/span><\/i> \u300d\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p class=\"c-paragraph\"><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p class=\"c-paragraph\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u306e\u5168\u6587\u306f\u3001\u6771\u4eac\u79d1\u5b66\u5927\u5b66\u306e<a href=\"https:\/\/www.isct.ac.jp\/ja\/news\/fdiru11e82hq\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u306e\u30da\u30fc\u30b8\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n","protected":false},"featured_media":10473,"template":"","news_events_cat":[9],"acf":[],"_links":{"self":[{"href":"https:\/\/www.elsi.jp\/wp-json\/wp\/v2\/news_events\/10515"}],"collection":[{"href":"https:\/\/www.elsi.jp\/wp-json\/wp\/v2\/news_events"}],"about":[{"href":"https:\/\/www.elsi.jp\/wp-json\/wp\/v2\/types\/news_events"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.elsi.jp\/wp-json\/wp\/v2\/media\/10473"}],"wp:attachment":[{"href":"https:\/\/www.elsi.jp\/wp-json\/wp\/v2\/media?parent=10515"}],"wp:term":[{"taxonomy":"news_events_cat","embeddable":true,"href":"https:\/\/www.elsi.jp\/wp-json\/wp\/v2\/news_events_cat?post=10515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}