Shawn McGlynn

Shawn McGlynn
氏 名
Shawn McGlynn
役 職


NASA Early Career Fellowship Award, 2014
Agouron Post-Doctoral Scholar, Caltech 2012
Silvan Scheller, Hang Yu, Grayson L. Chadwick, Shawn E. McGlynn, Victoria J. Orphan. Artificial electron acceptors decouple archaeal methane oxidation from sulfate reduction. Science 2016, 351 (6274). pp. 703-707.
Scharf et alia. A strategy for Origins of Life Research. Astrobiology 2015, 15 (12), 1031-1042.
Shawn E. McGlynn, Grayson L. Chadwick, Christopher P. Kempes, and Victoria J. Orphan. Single cell activity reveals direct electron transfer in methanotrophic consortia. Nature, 2015 526, 531–535.
Elizabeth Trembath-Reichert, Jonathan P Wilson, Shawn E McGlynn, Woodward W Fischer. Four hundred million years of silica biomineralization in land plants. Proc Natl Acad Sci U S A. 2015 112, 5449-5454
Sebastian H Kopf, Shawn E McGlynn, Abigail Green‐Saxena, Yunbin Guan, Dianne K Newman, Victoria J Orphan. Heavy water and 15N labelling with NanoSIMS analysis reveals growth rate‐dependent metabolic heterogeneity in chemostats. Environ Microbiol. 2015 17 (7), 2542-2556
Patricia L Tavormina, Roland Hatzenpichler, Shawn McGlynn, Grayson Chadwick, Katherine S Dawson, Stephanie A Connon, Victoria J Orphan. Methyloprofundus sedimenti gen. nov., sp. nov., an obligate methanotroph from ocean sediment belonging to the ‘deep sea-1’clade of marine methanotrophs. Int J Syst Evol Microbiol. 2015 Jan;65(Pt 1):251-9.
Russell MJ, Barge LM, Bhartia R, Bocanegra D, Bracher PJ, Branscomb E, Kidd R, McGlynn S, Meier DH, Nitschke W, Shibuya T, Vance S, White L, Kanik I. The Drive to life on wet and icy worlds. Astrobiology. 2014 Apr;14(4):308-43
Elitza I. Tocheva, Anne E. Dekas, Shawn E. McGlynn, David Morris, Victoria J. Orphan, Grant J. Jenson. Polyphosphate storage during sporulation in the Gram-negative bacterium Acetonema longum. J. Bact. 2013, 195(17): 3940.
Wolfgang Nitschke, Shawn E. McGlynn, James E. Milner-White, Michael J. Russell. On the antiquity of metalloenzymes and their substrates in bioenergetics. Biochim Biophys Acta 2013, 1827: 871-881.
Shawn E. McGynn, Eric S. Boyd, John W. Peters and Victoria J Orphan. Classifying the metal dependence of uncharacterized nitrogenases. Front. Microbiol., 2013, 3:419
Shawn E. McGlynn, Isik Kanik, and Michael J. Russell. Peptide and RNA contributions to FeS chemical gardens as life’s first inorganic compartments, catalysts, capacitors and condensers. Phil. Trans. R. Soc. A. 2012, 370, 1–16
Randall E. Mielke, Kirtland J. Robinson, Lauren M. White, Shawn E. McGlynn, Kavan McEachern, Rohit Bhartia, Isik Kanik and Michael J. Russell. Iron-sulfide-bearing chimneys as potential catalytic energy traps at life’s emergence, Astrobiology, 2011, Vol. 11 (10)
(1) Aaron D. Goldman and Shawn E. McGlynn. What is Life? (2) Jeff S. Bowman and Shawn E. McGlynn. How does life on Earth obtain energy from the environment?
(3) Jen B. Glass and Shawn E. McGlynn. How do life and global geochemical cycles mutually affect each other? Invited and submitted to appear in the Astrobiology Primer: An Outline of General Knowledge 2011.
Nathan Haydon, Shawn E. McGlynn, and Olin Robus; Speculation on quantum mechanics and the Emergence of Life Giving Catalysts. Ori. Life. Evol. Bio. 2011 Feb;41(1):35-50.
Randall E. Mielke, Michael J. Russell, Philip R. Wilson, Shawn E. McGlynn, Max Coleman, Richard D. Kidd, and Isik Kanik. Design, Fabrication and Test of a Hydrothermal Reactor for Origin-Of-Life Experiments. Astrobiology, 2010 Oct;10(8):799-810.
Eric M. Shepard, Benjamin R. Duffus, Simon J. George, Shawn E. McGlynn, Martin R. Challand, Kevin D Swanson, Peter L. Roach, Stephen P. Cramer, John W. Peters, and Joan B. Broderick. [FeFe]-Hydrogenase Maturation: HydG-Catalyzed Synthesis of Carbon Monoxide. JACS, 2010 Jul 14;132(27):9247-9.
Eric M. Shepard, Shawn E. McGlynn, Alexandra L. Bueling, Celestine S. Grady-Smith, Simon J. George, Mark A. Winslow, Stephen P. Cramer, John W. Peters, and Joan B. Broderick. Synthesis of the 2Fe-subcluster of the [FeFe]-hydrogenase H- cluster on the HydF scaffold. PNAS, 2010 Jun 8;107(23):10448-53.
Rebecca C. Driesener, Martin R. Challand, Shawn E. McGlynn, Eric M. Shepard, Eric S. Boyd, Joan B. Broderick, John W. Peters and Peter L. Roach. [FeFe]-Hydrogenase Cyanide Ligands Derived From S-Adenosylmethionine Dependent Cleavage of Tyrosine. Angewandte Chemie. 2010, Feb 9: 1687-1690
Shawn E. McGlynn, Eric S. Boyd, Eric M. Shepard, Rachel Lange, Robin Gerlach, Joan B. Broderick, and John W. Peters. Identification and characterization of a novel member of the radical AdoMet enzyme superfamily and implications for the biosynthesis of the Hmd hydrogenase active site cofactor. J. Bacteriol. 2010, January 192 (2) 595-598.
Reed Taffs, John E. Aston, Kristen Brileya, Zackary Jay, Christian G Klatt, Shawn E. McGlynn, Natatsha Mallette, Scott Montross, Robin Gerlach, William P Inskeep, David M Ward, and Ross Carlson. In silico approaches to study mass and energy flows in microbial consortia: a syntrophic case study. BMC Systems Biology 2009, 3: 114
Shawn E. McGlynn, David W. Mulder, Eric M. Shepard, Joan B. Broderick, and John W. Peters. Hydrogenase cluster biosynthesis: organometallic chemistry nature’s way, Dalton Trans. 2009 Jun 14;(22):4274-85.
Shawn E. McGlynn, Eric M. Shepard, Mark A. Winslow, Anatoli V. Naumov, Kaitlin S. Duschene, Matthew C. Posewitz, William E. Broderick, Joan B. Broderick, and John W. Peters. HydF as a scaffold protein in [FeFe] hydrogenase maturation. FEBS Lett. 2008 Jun 25;582(15):2183-7
Shawn E. McGlynn, Shane S. Ruebush, Anatoli Naumov, Lauren E. Nagy, Alexandra Dubini, Paul W. King, Joan B. Broderick, Matthew C. Posewitz, and John W. Peters. In vitro activation of [FeFe] hydrogenase: new insights into hydrogenase maturation, Journal of Biological Inorganic Chemistry. May;12, 2007 (4):443-7.


Keywords: microbial interactions, metalloproteins, early life and its emergence, stable isotope techniques, microbial ecology
My interests stem from my basic curiosity to understand matter and energy relationships in biological processes, especially those that may lead to insights into how life started. Current projects seek to investigate hydrogen oxidation and carbon reduction in hydrothermal vent simulation experiments, the sulfur isotope fractionation factors of the enzymes involved in microbial dissimilatory sulfate reduction, and direct interspecies electron transfer as a mechanism of syntrophic metabolic coupling. Other topics include the microbial ecology of hot springs in Japan with relevance to early ocean chemistry, and metal abundance distributions across microbial taxa.
Please contact me if you would like to discuss research on these topics, or others at ELSI!