Research & Activities


Hongo, Yayoi

Hongo, Yayoi
Hongo, Yayoi
Chemistry Lab Manager
Analytical chemistry

Main Publication List and Awards

23. Shunya Takahashi, Ayaka Yoshida, Shota Uesugi, Yayoi Hongo, Ken-ichi Kimura, Koji Matsuoka, Hiroyuki Koshino. ” Structural revision of kynapcin-12 by total synthesis, and inhibitory activities against prolyl oligopeptidase and cancer Cells”, Bioorganic & Medicinal Chemistry Letters (2014), 24(15), 3373-3376. DOI:10.1016/j.bmcl.2014.05.091

22. Yayoi Hongo, Takemichi Nakamura, Shunya Takahashi, Takayuki Motoyama, Toshiaki Hayashi, Hiroshi Hirota, Hiroyuki Osada, Hiroyuki Koshino. “Detection of oxygen addition peaks for terpendole E and related indole-diterpene alkaloids in a positive-mode ESI-MS” Journal of Mass Spectrometry (2014), 49(6), 537-542. DOI:10.1002/jms.3360

21. Chung Liang Lim, Toshihiko Nogawa, Masakazu Uramoto, Akiko Okano, Yayoi Hongo, Takemichi Nakamura, Hiroyuki Koshino, Shunji Takahashi, Darah Ibrahim, Hiroyuki Osada. “RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening” Journal of Antibiotics (2014), 67(4), 323-329. DOI:10.1038/ja.2013.144

20. Yue Qi Ye, Chiemi Negishi, Yayoi Hongo, Hiroyuki Koshino, Jun-ichi Onose, Naoki Abe, Shunya Takahashi. “Structural elucidation and synthesis of vialinin C, a new inhibitor of TNF-a production” Bioorganic & Medicinal Chemistry (2014), 22(8), 2442-2446. DOI:10.1016/j.bmc.2014.02.058

19. Yayoi Hongo, Baolin Li, Katsunori Suzuki, Takemichi Nakamura. “An unexpected [M+I]+ ion formation in phosphasilene compounds detection by electrospray ionization mass spectrometry” Journal of Mass Spectrometry (2011), 46(9), 956-959. DOI:10.1002/jms.1975

18. Tasuku Akagi, Feng-Fu Fu, Yayoi Hongo, Kozo Takahashi,“Composition of rare earth elements in settling particles collected in the highly productive North Pacific Ocean and Bering Sea: Implications for siliceous-matter dissolution kinetics and formation of two REE-enriched phases” Geochimica et Cosmochimica Acta (2011), 75(17), 4857-4876. DOI:10.1016/j.gca.2011.06.001

17. Yuko Izuchi, Hiroyuki Koshino, Yayoi Hongo, Nobuhiro Kanomata, Shunya Takahashi, “Synthesis and Structural Revision of Phomopsin B, a Novel Polyketide Carrying a 10-Membered Cyclic-Ether Ring” Organic Letters (2011), 13(13), 3360-3363. DOI:10.1021/ol2011117

16. Shunya Takahashi, Yayoi Hongo, Yue Qi Ye, Hiroyuki Koshino. “Simple and efficient synthesis of highly functionalized cyclohexanes; formal total synthesis of ovalicin and fumagillin” Tetrahedron: Asymmetry (2011), 22(6), 703-707. DOI:10.1016/j.tetasy.2011.03.015

15. Yuko Izuchi, Nobuhiro Kanomata, Hiroyuki Koshino, Yayoi Hongo, Tadashi Nakata, Shunya Takahashi. “Formal total synthesis of aspergillide A” Tetrahedron: Asymmetry (2011), 22(2), 246-251. DOI:10.1016/j.tetasy.2011.01.016

14. Yasuko Hara, Hajime Obata, Takashi Doi, Yayoi Hongo, Toshitaka Gamo, Shigenobu Takeda, Atsushi Tsuda. “Rare earth elements in seawater during an iron-induced phytoplankton bloom of the western subarctic Pacific (SEEDS-II)” Deep-Sea Research, Part II: Topical Studies in Oceanography (2009), 56(26), 2839-2851. DOI:10.1016/j.dsr2.2009.06.009

13. Shunya Takahashi, Ryotaro Takahashi, Yayoi Hongo, Hiroyuki Koshino, Kazunori Yamaguchi, Taeko Miyagi. “Synthesis of all possible isomers corresponding to the proposed structure of montanacin E, and their antitumor activity” Journal of Organic Chemistry (2009), 74(16), 6382-6385. DOI:10.1021/jo901150h

12. Hiroko Tani, Shunya Takahashi, Keiko Hasumi, Tomoki Tatefuji, Yayoi Hongo, Hiroyuki Koshino. “Isolation of (E)-9,10-dihydroxy-2-decenoic acid from royal jelly and determination of the absolute configuration by chemical synthesis” Tetrahedron: Asymmetry (2009), 20(4), 457-460. DOI:10.1016/j.tetasy.2009.01.028

11. Shunya Takahashi, Yayoi Hongo, Yuki Tsukagoshi, Hiroyuki Koshino, “Structural determination of montanacin D by total synthesis” Organic Letters (2008), 10(19), 4223-4226. DOI:10.1021/ol801576z

10. Kouichi Sugaya, Hiroyuki Koshino, Yayoi Hongo, Katsuaki Yasunaga, Jun-ichi Onose, Kunie Yoshikawa, Naoki Abe. “The biosynthesis of sorbicillinoids in Trichoderma sp. USF 2690: Prospect for the existence of a common precursor to sorbicillinol and 5-epihydroxyvertinolide, a new sorbicillinoid member” Tetrahedron Letters (2008), 49(4), 654-657. DOI:10.1016/j.tetlet.2007.11.121 

9. Yayoi Hongo, Akihiro Sato, Takemichi Nakamura. ” Factors governing peptide backbone cleavages in electron capture dissociation of triantennary complex-type Nglycosylated peptide” Journal of the Mass Spectrometry Society of Japan (2007), 55(4), 279-285. DOI:10.5702/massspec.55.279

8. Yayoi Hongo, Takemichi Nakamura, Akihiro Sato. “Electron capture dissociation of triantennary complex-type N-glycosylated peptides: a case of suppressed peptide backbone cleavage” Journal of the Mass Spectrometry Society of Japan (2007), 55(2), 77-82. DOI:10.5702/massspec.55.77

7. Takahiro Aze, Hiroyuki Matsuzaki, Hiroshi Matsumura, Hisao Nagai, Masatsugu Fujimura, Mayum Noguchi, Yayoi Hongo, Yusuke Yokoyama. “Improvement of the 36Cl-AMS system at MALT using a Monte Carlo ion-trajectory simulation in a gas-filled magnet” Nuclear Instruments & Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms (2007), 259(1), 144-148 DOI:10.1016/j.nimb.2007.01.154

6. Shunya Takahashi, Hiroko Satoh, Yayoi Hongo, Hiroyuki Koshino, “Structural Revision of Terpenoids with a (3Z)-2-Methyl-3-penten-2-ol Moiety by the Synthesis of (23E)- and (23Z)-Cycloart-23-ene-3b,25-diols” Journal of Organic Chemistry (2007), 72(12), 4578-4581. DOI:10.1021/jo070478m

5. Yayoi Hongo, Hajime Obata, Toshitaka Gamo, Miwako Nakaseama, Junichiro Ishibashi, Uta Konno, Shunsuke Saegusa, Satoru Ohkubo, Urumu Tsunogai, “Rare Earth Elements in the hydrothermal system at Okinawa Trough back-arc basin” Geochemical Journal (2007), 41(1), 1-15. DOI:10.2343/geochemj.41.1

4. Hajime Obata, Takashi Doi, Yayoi Hongo, Dia Sotto Alibo, Hideki Minami, Yoshihisa Kato, Masahiro Maruo. “Manganese, cerium and iron in the Sulu, Celebes and Philippine Seas” Deep-Sea Research, Part II: Topical Studies in Oceanography (2007), 54(1-2), 38-49. DOI:10.1016/j.dsr2.2006.09.004

3. Yayoi Hongo, Hajime Obata, Dia Sotto Alibo, Yoshiyuki Nozaki, “Spatial variations on rare earth elements in North Pacific surface water” Journal of Oceanography (2006), 62(4), 441-455. DOI:10.1007/s10872-006-0067-1

2. Shunya Takahashi, Yayoi Hongo, Narihito Ogawa, Hiroyuki Koshino, Tadashi Nakata, “Convergent Synthesis of Pyragonicin” Journal of Organic Chemistry (2006), 71(16), 6305-6308. DOI:10.1021/jo060970q

1. Yayoi Hongo, Yoshiyuki Nozaki, “Rare earth element geochemistry of hydrothermal deposits and Calyptogena shell from the Iheya Ridge vent field,Okinawa Trough”Geochemical Journal (2001), 35(5), 347-354.DOI:10.2343/geochemj.35.347


Mass Spectrometry Society of Japan, MSSJ Research Award, May 2014

RIKEN Technology Incentive Award, “Development of advanced methods for chemical biology research” March 2013.

Award of excellence, The 55th Annual Conference on mass Spectrometry Japan, May 2007
Structural information obtained by the MS/MS experiments in FT-ICR cell and fragmentation mechanisms

Best poster award. The 21st Century Center Of Excellence Program, The University of Tokyo, The 2nd joint symposium on Human-Friendly Material based on Chemistry. “Spatial variations on rare earth elements in Pacific surface water” June 2004.

Research Interests

New analytical methods using mass spectrometry will be studied for various samples in ELSI. Ionization and ion dissociation techniques are keys to detect target compounds. I’m looking forward to working with you.